I've got multiple projects going on lately, and none of them are finished. So instead of turning off my computer, I've just been putting it into sleep mode or hibernation.
The result? Almost 30 days of uptime, and no issues whatsoever. Windows 10 is awesome.
I've been making full use of Windows 10's multiple desktops too. Been wishing for it since I first used Ubuntu in 2009. Really helps keep things organized. I've got one for my main misc stuff, one for my current web design project, and one for audio editing.